Emma Bolderson Selected Research

Therapeutics

1/2024	Inhibition of Aurora B kinase (AURKB) enhances the effectiveness of 5-fluorouracil chemotherapy against colorectal cancer cells.
1/2024	The expression and role of the Lem-D proteins Ankle2, Emerin, Lemd2, and TMPO in triple-negative breast cancer cell growth.
9/2023	Mono-phosphorylation at Ser4 of barrier-to-autointegration factor (Banf1) significantly reduces its DNA binding capability by inducing critical changes in its local conformation and DNA binding surface.
1/2023	hSSB1 (NABP2/OBFC2B) modulates the DNA damage and androgen-induced transcriptional response in prostate cancer.
12/2022	The role of inner nuclear membrane proteins in tumourigenesis and as potential targets for cancer therapy.
9/2021	Elevating CDCA3 Levels Enhances Tyrosine Kinase Inhibitor Sensitivity in TKI-Resistant EGFR Mutant Non-Small-Cell Lung Cancer.
1/2021	Elevating CDCA3 levels in non-small cell lung cancer enhances sensitivity to platinum-based chemotherapy.
1/2021	Cell Metabolism and DNA Repair Pathways: Implications for Cancer Therapy.
1/2021	Identification of Proteins Deregulated by Platinum-Based Chemotherapy as Novel Biomarkers and Therapeutic Targets in Non-Small Cell Lung Cancer.
1/2021	Beyond PARP1: The Potential of Other Members of the Poly (ADP-Ribose) Polymerase Family in DNA Repair and Cancer Therapeutics.

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Emma Bolderson Research Topics

Disease

14	Neoplasms (Cancer) 04/2024 - 06/2006
12	Genomic Instability 01/2023 - 05/2008
7	Ataxia Telangiectasia (Louis Bar Syndrome) 01/2023 - 12/2004
4	Lung Neoplasms (Lung Cancer) 12/2023 - 01/2020
4	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 09/2021 - 10/2020
3	Breast Neoplasms (Breast Cancer) 01/2024 - 05/2014
3	Progeria (Hutchinson Gilford Syndrome) 01/2021 - 12/2014
2	Triple Negative Breast Neoplasms 01/2024 - 05/2014
2	Adenocarcinoma 09/2021 - 10/2020
2	Chromosomal Instability (Chromosome Stability) 04/2010 - 08/2009
2	Hypersensitivity (Allergy) 04/2010 - 08/2009
1	Colorectal Neoplasms (Colorectal Cancer) 01/2024
1	Cicatrix (Scar) 01/2023
1	Prostatic Neoplasms (Prostate Cancer) 01/2023
1	Xeroderma Pigmentosum (Kaposi's Disease) 10/2021
1	Premature Aging 01/2021
1	Ovarian Neoplasms (Ovarian Cancer) 01/2020
1	Chromosome Aberrations (Chromosome Abnormalities) 06/2014
1	Familial Breast Cancer 05/2014
1	Genetic Translocation (Chromosomal Translocation) 01/2014

Drug/Important Bio-Agent (IBA)

18	Proteins (Proteins, Gene)FDA Link 01/2024 - 10/2009
15	DNA (Deoxyribonucleic Acid)IBA 09/2023 - 12/2004
6	Phosphotransferases (Kinase)IBA 01/2023 - 12/2004
4	1,2- di- (4- sulfamidophenyl)- 4- butylpyrazolidine- 3,5- dione (DSB)IBA 01/2023 - 04/2010
4	PlatinumIBA 09/2021 - 01/2020
3	Messenger RNA (mRNA)IBA 04/2024 - 01/2016
3	Biomarkers (Surrogate Marker)IBA 01/2021 - 05/2014
3	ChromatinIBA 01/2021 - 08/2012
3	Cisplatin (Platino)FDA LinkGeneric 01/2021 - 01/2020
3	DNA-Binding Proteins (DNA Binding Protein)IBA 04/2013 - 05/2008
2	Small Interfering RNA (siRNA)IBA 01/2024 - 11/2016
2	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA 01/2021 - 10/2009
2	chloropyramineIBA 10/2020 - 11/2016
2	Indicators and Reagents (Reagents)IBA 10/2020 - 08/2009
2	Poly(ADP-ribose) Polymerase InhibitorsIBA 01/2020 - 10/2009
1	Aurora Kinase BIBA 01/2024
1	Fluorouracil (Carac)FDA LinkGeneric 01/2024
1	Hormones (Hormone)IBA 01/2024
1	3,3,5,5-tetramethyl-1-pyrroline N-oxide (TMPO)IBA 01/2024
1	emerinIBA 01/2024
1	Androgen Receptors (Androgen Receptor)IBA 01/2023
1	Glucose (Dextrose)FDA LinkGeneric 01/2023
1	DNA-Activated Protein KinaseIBA 01/2023
1	AndrogensIBA 01/2023
1	Transcription Factors (Transcription Factor)IBA 01/2023
1	Tyrosine Kinase InhibitorsIBA 09/2021
1	ErbB Receptors (EGF Receptor)IBA 09/2021
1	Cytotoxins (Cytolysins)IBA 01/2021
1	Carboplatin (JM8)FDA LinkGeneric 01/2021
1	lysyl- arginyl- alanyl- lysyl- alanyl- lysyl- threonyl- threonyl- lysyl- lysyl- arginine (PKCS)IBA 01/2021
1	Immunoconjugates (Immunoconjugate)IBA 01/2020
1	NucleophosminIBA 01/2016
1	Alanine (L-Alanine)FDA Link 12/2014
1	Threonine (L-Threonine)FDA Link 12/2014
1	CamptothecinIBA 06/2014
1	HeterochromatinIBA 08/2012
1	Co-Repressor ProteinsIBA 08/2012
1	human EXO1 proteinIBA 04/2010
1	Antineoplastic Agents (Antineoplastics)IBA 10/2009
1	Carrier Proteins (Binding Protein)IBA 10/2009
1	dimemorfan (AT 17)IBA 06/2006
1	Ataxia Telangiectasia Mutated ProteinsIBA 12/2004

Therapy/Procedure

15	Therapeutics 01/2024 - 10/2009
7	Drug Therapy (Chemotherapy) 01/2024 - 10/2009
3	Immunotherapy 01/2021 - 01/2020
1	Radiotherapy 01/2023